Apexion Health Enclomiphene oral tablets
HORMONESERM

MONTHLY SUPPLY · ORAL TABLET

ENCLOMIPHENE

TREATMENT

Raise natural testosterone while preserving fertility

SUPPORT

Enclomiphene is a selective estrogen receptor modulator (SERM) that blocks estrogen feedback at the hypothalamus and pituitary, driving endogenous LH and FSH release and elevating natural testosterone production without suppressing spermatogenesis.

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Lab-Tested · Physician-Supervised · Discreet Delivery

Apexion Health — HORMONE

RAISE YOUR OWN TESTOSTERONE. KEEP YOUR FERTILITY.

Exogenous testosterone suppresses the hypothalamic-pituitary-gonadal (HPG) axis — shutting down LH, FSH, and endogenous testosterone production, and impairing sperm production. Enclomiphene, the trans-isomer of clomiphene, blocks hypothalamic estrogen receptors, tricking the pituitary into releasing more LH and FSH. The result: your testes increase their own testosterone output naturally, without shutting down the axis. Ideal for men who want hormone optimization while maintaining fertility or who prefer to avoid exogenous testosterone.

Clinical Benefits

ENCLOMIPHENE SUPPORTS YOUR HEALTH AT THE CELLULAR LEVEL

  1. 01.

    STIMULATES ENDOGENOUS LH AND FSH RELEASE FROM THE PITUITARY

  2. 02.

    RAISES NATURAL TESTOSTERONE WITHOUT AXIS SUPPRESSION

  3. 03.

    PRESERVES SPERMATOGENESIS AND FERTILITY POTENTIAL

  4. 04.

    AVOIDS TESTICULAR ATROPHY ASSOCIATED WITH EXOGENOUS TRT

  5. 05.

    ORAL DAILY TABLET — NO INJECTIONS REQUIRED

  6. 06.

    PHYSICIAN-MONITORED WITH HORMONE AND SEMEN PANELS

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Clinical Evidence

How It Works in the Body

01 — Dose & Efficacy

Endogenous T Restoration

LH Restoration Endogenous gonadotropin recovery60%
FSH Preservation Spermatogenesis maintained85%
Fertility Preservation Unlike exogenous TRT100%

Wiehle et al., BJU Int 2013; Rodriguez et al., J Sex Med 2016

02 — Hormone Panel

HPG Axis Restoration

MarkerWithoutWith Treatment
Total Tng/dL
210
490+280
Free Tpg/mL
46
115+69
LHIU/L
3.8
11.2+7.4
Estradiolpg/mL
22
35+13

Preserves HPG axis feedback and fertility

Blocks estrogen negative feedback at hypothalamus, increasing GnRH pulse frequency. Unlike TRT, FSH is preserved — spermatogenesis continues. Ideal for men desiring fertility.

Wiehle et al., BJU Int 2013; Kim et al., BJU Int 2016

03 — Protocol

Enclomiphene Protocol

BaselinePre-treatment
  • ›Total T, free T (2× AM draw)
  • ›LH, FSH, estradiol
  • ›Semen analysis if fertility concern
TitrationMonths 1–3
  • ›Start 12.5–25 mg oral daily
  • ›Total T & LH at 4 weeks
  • ›Titrate based on response
MaintenanceMonth 4+
  • ›Total T, free T, E2 q3–6 months
  • ›Semen at 6 months if fertility goal
  • ›PSA & Hct annual

Oral daily dosing — fertility-friendly

Typical start 12.5–25 mg once daily. Target total T 400–700 ng/dL. Unlike TRT, Hct elevation is unusual. Visual disturbances ~0.5% (dose-related). Not FDA-approved as single enantiomer in US.

All protocols physician-supervised and adjusted per individual labs.