Apexion Health HCG injection vial
HORMONEFERTILITY

3-MONTH SUPPLY · INJECTION

HCG

TREATMENT

Human chorionic gonadotropin for fertility and testosterone support

SUPPORT

Human chorionic gonadotropin (hCG) is a glycoprotein hormone that mimics luteinizing hormone (LH), stimulating Leydig cell testosterone production and Sertoli cell support of spermatogenesis — used in male fertility protocols and as an adjunct to TRT to prevent testicular atrophy.

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Lab-Tested · Physician-Supervised · Discreet Delivery

Apexion Health — HORMONE

MAINTAIN TESTICULAR FUNCTION. SUPPORT FERTILITY.

HCG is a glycoprotein hormone that shares structural homology with LH and binds the LH/hCG receptor on Leydig cells in the testes. At physiological doses, it drives intratesticular testosterone production and supports Sertoli cell function — the cells responsible for maintaining spermatogenesis. For men on exogenous TRT, HCG co-administration prevents the LH suppression-induced testicular atrophy and maintains intratesticular testosterone at levels necessary for sperm production. For men seeking to restore natural testosterone production, HCG monotherapy or combination with SERMs is a primary fertility-preserving approach.

Clinical Benefits

HCG SUPPORTS YOUR HEALTH AT THE CELLULAR LEVEL

  1. 01.

    STIMULATES LEYDIG CELLS TO PRODUCE INTRATESTICULAR TESTOSTERONE

  2. 02.

    MAINTAINS SPERMATOGENESIS DURING OR AFTER TRT

  3. 03.

    PREVENTS TESTICULAR ATROPHY FROM LH SUPPRESSION

  4. 04.

    SUPPORTS FERTILITY PROTOCOLS IN HYPOGONADAL MEN

  5. 05.

    USED AS MONOTHERAPY OR ADJUNCT TO TRT

  6. 06.

    PHYSICIAN-SUPERVISED 3-MONTH INJECTABLE SUPPLY

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Clinical Evidence

How It Works in the Body

01 — Dose & Efficacy

Intratesticular T Preservation

Sperm Concentration Maintained vs TRT-alone collapse75%
LH Receptor Activation Mimics endogenous LH signaling85%
Testicular Volume Prevents TRT-induced atrophy70%

Coviello et al., JCEM 2005; Hsieh et al., J Urol 2013

02 — Hormone Panel

Testicular Function: TRT vs TRT+HCG

MarkerWithoutWith Treatment
Intratesticular Tng/mL
~50–100 (TRT)
~600–1000+~+900
Sperm ConcentrationM/mL
<1 (TRT alone)
MaintainedPreserved
LH Bioactivity—
Suppressed
Mimicked (HCG)Functional
Testicular VolumemL
−30% (TRT alone)
MaintainedPreserved

HCG is an LH analog that preserves endogenous T production

Exogenous T suppresses LH/FSH, collapsing ITT and impairing spermatogenesis. HCG directly stimulates Leydig cells to maintain ITT. Foundation of fertility-preserving TRT.

Coviello et al., JCEM 2005; Hsieh et al., J Urol 2013

03 — Protocol

HCG + TRT Co-Therapy Protocol

BaselinePre-treatment
  • ›Semen analysis (WHO criteria)
  • ›Total T, free T, LH, FSH, E2
  • ›Testicular volume
Co-TherapyMonths 1–3
  • ›HCG 500 IU SC 3×/week + TRT
  • ›Total T & E2 at 4 weeks
  • ›Adjust HCG dose by response
FertilityMonth 3+
  • ›Semen analysis at 3 & 6 months
  • ›Total T, E2 q3 months
  • ›Add AI if E2 >50 pg/mL

Typical HCG: 500 IU SC EOD (or 3×/week)

Monitor estradiol: HCG stimulates aromatization, E2 commonly rises. Add anastrozole 0.5–1 mg 2×/week if E2 elevated. HCG monotherapy at higher doses for fertility-focused treatment.

All protocols physician-supervised and adjusted per individual labs.