Apexion Health Progesterone oral capsules
HORMONEWOMEN'S HEALTH

MONTHLY SUPPLY · ORAL TABLET

PROGESTERONE

TREATMENT

Bioidentical progesterone for hormone balance, sleep, and mood

SUPPORT

Micronized bioidentical progesterone (USP) restores progesterone levels in perimenopausal and postmenopausal women, supporting uterine health as estrogen co-therapy, improving sleep architecture, and stabilizing mood through GABA receptor modulation.

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Lab-Tested · Physician-Supervised · Discreet Delivery

Apexion Health — HORMONE

PROGESTERONE. THE CALMING COUNTERPART TO ESTROGEN.

Progesterone is produced primarily by the corpus luteum during the luteal phase and by the placenta during pregnancy. As cycles become irregular in perimenopause, progesterone declines before estrogen — a hormonal imbalance that contributes to sleep disruption, anxiety, mood changes, and irregular bleeding. Micronized bioidentical progesterone (identical in structure to endogenous progesterone) is taken orally, where its conversion to allopregnanolone activates GABA-A receptors — explaining the sedative, anxiolytic, and sleep-promoting effects distinct from synthetic progestins.

Clinical Benefits

PROGESTERONE SUPPORTS YOUR HEALTH AT THE CELLULAR LEVEL

  1. 01.

    PROVIDES ENDOMETRIAL PROTECTION AS CO-THERAPY WITH ESTROGEN

  2. 02.

    PROMOTES SLEEP ONSET AND DEEP SLEEP VIA GABA-A MODULATION

  3. 03.

    REDUCES ANXIETY AND SUPPORTS MOOD STABILITY

  4. 04.

    BIOIDENTICAL STRUCTURE — IDENTICAL TO ENDOGENOUS PROGESTERONE

  5. 05.

    ORAL MICRONIZED FORMULATION FOR OPTIMAL ABSORPTION

  6. 06.

    PHYSICIAN-MONITORED HORMONE BALANCE PROTOCOL

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Clinical Evidence

How It Works in the Body

01 — Dose & Efficacy

Endometrial Protection with HRT

Sleep Quality Improved via GABA-ergic metabolites65%
Anxiety Reduction Allopregnanolone neurosteroid effect40%
Hyperplasia Prevention >90% protection vs unopposed E93%

PEPI Trial, JAMA 1996; REPLENISH, Obstet Gynecol 2018

02 — Hormone Panel

Clinical Outcomes with Progesterone Co-Therapy

MarkerWithoutWith Treatment
Endometrial Hyperplasia%
20–30%
<1%→>90% protection
Sleep Onset Latencymin
45
30−15
Night Sweats/week
5
1−4
Breast Cancer Risk (>5yr)RR
1.0
~1.26+26% (WHI, MPA)

Micronized progesterone preferred over synthetic progestins

Bioidentical micronized progesterone has more favorable metabolic/CV profile than MPA (WHI). Does not attenuate estrogen’s HDL benefit. May have lower breast cancer risk. 100–200 mg at bedtime.

PEPI, JAMA 1996; WHI, JAMA 2002; NAMS 2022 Position Statement

03 — Protocol

Progesterone Dosing Protocol

BaselinePre-treatment
  • ›Endometrial evaluation (TVUS if indicated)
  • ›Symptom diary
  • ›Sleep quality assessment
InitiationMonth 1
  • ›Micronized prog 100 mg nightly (continuous) OR 200 mg × 10–14 days/mo (cyclic)
  • ›Symptom & bleeding tracking
Long-termMonth 3+
  • ›Symptom reassessment q6 months
  • ›Annual endometrial assessment
  • ›Sleep & mood tracking

Always paired with estrogen in women with a uterus

Continuous combined (daily E+P) avoids withdrawal bleeding. Cyclic may produce scheduled bleeding. Take at bedtime to minimize daytime drowsiness.

All protocols physician-supervised and adjusted per individual labs.